Detecting past changes of effective population size

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Detecting past changes of effective population size

Understanding and predicting population abundance is a major challenge confronting scientists. Several genetic models have been developed using microsatellite markers to estimate the present and ancestral effective population sizes. However, to get an overview on the evolution of population requires that past fluctuation of population size be traceable. To address the question, we developed a n...

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Inferring Past Effective Population Size from Distributions of Coalescent Times

Inferring and understanding changes in effective population size over time is a major challenge for population genetics. Here we investigate some theoretical properties of random-mating populations with varying size over time. In particular, we present an exact solution to compute the population size as a function of time, [Formula: see text], based on distributions of coalescent times of sampl...

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Population size does not explain past changes in cultural complexity.

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Effective population size

What is it? An aid to calculation in population genetics, introduced by Sewall Wright. The rate of change of the genetic make-up of a population by genetic drift — fluctuations in allele frequencies caused by random sampling — is inversely related to the effective population size, Ne. Ne is measured with reference to an ideal ‘Wright–Fisher’ population. This has a fixed number of N diploid bree...

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Novel multilocus measure of linkage disequilibrium to estimate past effective population size.

Linkage disequilibrium (LD) between densely spaced, polymorphic genetic markers in humans and other species contains information about historical population size. Inferring past population size is of interest both from an evolutionary perspective (e.g., testing the "out of Africa" hypothesis of human evolution) and to improve models for mapping of disease and quantitative trait genes. We propos...

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ژورنال

عنوان ژورنال: Evolutionary Applications

سال: 2014

ISSN: 1752-4571,1752-4571

DOI: 10.1111/eva.12170